(1) sebenzisa "indlela yobunjiniyela benani" ekuthengeni imishini, izinqubo ezithile zimi kanje. Izidingo ezicacile, nquma imishini yokukhetha nokuthenga - ulwazi lwebhizinisi eliqondiwe (ulwazi luhlanganisa: inqubomgomo yokusebenza, umgomo wokuphatha, ubukhulu besimo sokukhiqiza nokuphatha, njll.) - umkhiqizo oqondiwe wahlaziywa, ukuhlaziywa kwemikhiqizo eqondiwe yenhlawulo, okungukuthi ukuhlukaniswa kwemisebenzi, umsebenzi othize nocacile, bese kuba ukuhlaziywa komsebenzi wemishini kanye nezinga lokufanisa lesidingo sangempela, kucatshangelwa ukusebenza kwemishini, uhlobo lokugxila olusebenzayo) - uhlelo lokuhlola (ngengxoxo yeqembu, ochwepheshe bokubonisana kanye nezinye izindlela ukuhlaziywa ngezinzuzo kanye nokungalungi kwemishini ukwenza ukuhlaziywa kwezindleko bese, ukuhlanganisa into eyinhloko, kanye nokuhlunga), ukunquma umgomo wokukhetha nokuthenga.

(2) ukufakwa nokwamukelwa kwemishini yezokwelapha. Ngokuhambisana ngokuqinile nezidingo ze-GMP kanye nezinqubo zokusebenza ezihlobene zokufakwa nokwamukelwa kwemishini yezokwelapha. Abahlanganyeli bafaka: ukukhiqiza, ubunjiniyela, ugesi, i-QA kanye nochwepheshe bangaphandle. Inqubo ethile yile: ukuqinisekiswa kokufakwa, ukuqinisekiswa kokusebenza. I-QA inesibopho sokuhlola nokuqinisekisa iphrojekthi ye-GMP, ukuhlolwa kanye nokuqinisekiswa.

(3) ukwakhiwa kolwazi. Ngokusho kwencwadi yezobuchwepheshe bemishini kanye ne-GMP, xhumana nochwepheshe abafanele, uhlanganise ithebula lokulungisa imishini kanye nencwadi yezobuchwepheshe, bese uqopha ngokuningiliziwe idatha yokulungisa yangaphambilini, izindlela zokulungisa kanye nemiphumela yokulungisa, ukuze kukhuthazwe ulwazi kanye nokuma okujwayelekile kokuphathwa nokugcinwa kwemishini yemithi.

(4) ukusebenzisa uhlelo "lwezikhathi ezimbili". Njengoba ukuphathwa kwemishini yezokwelapha kubonakaliswa ubungcweti obuqinile, izinkinga eziyinkimbinkimbi kanye nemikhakha ehlukahlukene, kanye nokungazelelwe nokufihlwa kokwehluleka kwemishini, kudinga ukuthi sisungule ukusebenza okusheshayo nokuphumelelayo, indlela yokuphendula kanye nokusingatha ukwehluleka ngesikhathi esifanele. Ukwaziswa kwe-shift (kubhekisela ekusetshenzisweni kwemizuzu eyi-10 ngaphambi kokuya emsebenzini nsuku zonke, ukufingqa nokuxoxa ngosuku olu-1 ngaphambi komsebenzi kanye nohlelo lomsebenzi walolu suku) kanye nomhlangano wamasonto onke womnyango (ukuhlolwa, ukubuyekezwa kokusebenza kuleli sonto, kuleli sonto ukuxoxa ngezinkinga eziyinhloko, ukuxoxa ngesisombululo, kanye nokusetha uhlelo lomsebenzi ngesonto elizayo), okungathuthukisa ngempumelelo ukwenziwa komsebenzi ojwayelekile, kubaluleke kakhulu ekunciphiseni ingozi yokuphepha efihliwe.